Our study suggests that this approach is feasible to detect interictal abnormalities in intracranial EEG, and of potential clinical value to identify pathological tissue in epilepsy. Normative mapping is a well-established practice in neuroscientific research. Third, we found that this effect discriminated patient outcomes (area under curve 0.75 P = 0.0003). Second, when accounting for the normative variations, regions that were spared by surgery were more abnormal than those resected only in patients with persistent postoperative seizures ( t = −3.6, P = 0.0003), confirming our hypothesis. We first confirmed that the spatial variations of band power in the normative map across brain regions were consistent with healthy variations reported in the literature. We proposed that if the most abnormal regions were spared by surgery, then patients would be more likely to experience continued seizures postoperatively. We then compared interictal recordings from 62 patients with epilepsy to the normative map to identify abnormal regions. To this end, we constructed a normative map of brain dynamics, in terms of relative band power, from interictal intracranial recordings from 234 participants (21 598 electrode contacts). Here, we investigate if such interictal abnormalities become more salient by quantitatively accounting for the range of healthy brain dynamics in a location-specific manner. However, this identification may be challenging during non-seizure (interictal) periods, especially if abnormalities are subtle compared to the repertoire of possible healthy brain dynamics. The identification of abnormal electrographic activity is important in a wide range of neurological disorders, including epilepsy for localizing epileptogenic tissue.
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